In Search of Lost Memories

Memory of a BeachMemory is not a fixed, static impression left on a person’s brain. Researchers have found that “the very act of remembering could change the memory,” Joseph LeDoux writes for the Scientist. Using that knowledge, his colleagues are working on ways that specific memories could be simply erased from people’s brains. LeDoux asks, “Could traumatic memories be dampened or erased simply by remembering?”

The research is already leading to experiments in lessening post traumatic stress disorder using drugs, as reported on Utne.com. Many have worry about the ethical implications of messing with people’s memories, but according to LeDoux, patients who suffer from reactions to memories they can’t control have said that they would rather risk losing a memory or two if it meant being able to remove the debilitating ones.”

People wouldn’t need to stop at bad memories, Greg Beato writes for Reason. Erasing the good memories from people’s brains could make life a lot more enjoyable. “Imagine falling in love for the first time, again and again and again,” Beato writes, “hearing your all-time favorite album with completely fresh ears; rediscovering the virtues of martinis.” People would no longer get bored with their jobs, their spouses, their music collections, and could continue to experience life as if for the first time.

Sources: The Scientist (subscription required), Reason

Image by Sergio Tudela, licensed under Creative Commons.

A Drug to Weaken PTSD

Technology ReviewHow we think about memory is about to change. Psychologist Alain Brunet, who works at McGill University and the Douglas Institute in Montreal, is conducting clinical trials in which participants take propranolol, a blood-pressure drug, after writing about a traumatic experience, reports Technology Review. This exercise seems to “weaken” the emotional strength of the memory, without disturbing any details. Six months after participating in a trial, one Canadian soldier suffering from posttraumatic stress disorder (PTSD) no longer qualified for the diagnosis.

Brunet’s research has to do with unlocking the secrets of how memories are stored, specifically proving the concept of memory reconsolidation. If Brunet is correct, when we recall a memory, it has to be packed away into the brain anew—and during that process the memory is malleable. If this is true, it opens up a bevy of possibilities for the treatment of PTSD, as well as other anxiety disorders and addiction.

There are some concerns that Brunet could be opening the proverbial Pandora’s box, but the psychologist isn’t fazed. “Brunet points out that he is trying to bring PTSD patients’ memories into a normal emotional range, not blunt their power altogether,” Technology Review senior editor Emily Singer writes. “He doesn’t think that using propranolol to render these memories bearable would create any unique potential for abuse as a way to dull the regrets, fears, and embarrassments of everyday life; people already use alcohol and drugs for such purposes.”

Source: Technology Review 

Erasing Specific Memories

MRI Brain ScanScientists believe they may have figured out a way to erase specific memories from animals’ brains, Science News reports. For the experiment, researchers subjected a mouse to a series of electric shocks while in a chamber and while playing a sound. The mouse naturally created a memory associating the sound and the chamber with the shocks. Using a protein known as alpha-CaMKII, the scientists were able to disassociate specific parts of the mouse’s memory, so the subject would become scared when placed in the chamber but not when the sound was made, or vice versa. This way, researchers believe they have discovered a way to target and block certain memories, leaving others in tact. 

The research may, in the future, lead to new ways to treat post-traumatic stress disorder, but Science a Go Go points out that a lot of work needs to be done before the scientists can start erasing specific memories in humans.




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